We found substantial variation in the abundance of the detected metabolites among isolates. We performed untargeted ultra-high performance liquid chromatography-high resolution mass spectrometry to profile the metabolite diversity among 102 isolates of the same species. The pathogen causes major yield losses and shows variation in gene clusters. Here, we analyzed the metabolite production of a large population of the fungal pathogen of wheat, Zymoseptoria tritici. However, the genetic basis underlying variation in SM production remains poorly understood. The acquisition, rearrangement, and deletion of gene clusters can generate significant metabolome diversity. Such gene clusters can undergo horizontal gene transfers between species and rapid evolutionary change within species. Pathways for the production of SMs are often encoded in clusters of tightly arranged genes identified as biosynthetic gene clusters. Fungi produce a wide range of specialized metabolites (SMs) involved in biotic interactions.
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